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[ccp4bb] research tech and postdoc positions at Brown University

Dear ccp4 enthusiasts,

There are two positions available in my lab at Brown University. More information below, and feel free to email me.




at Brown University (Structural Biology)


The Deaconescu Lab at Brown University is seeking a postdoctoral researcher. The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of DNA-based motors using a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Deaconescu et al., PNAS (2012), Szyk et al, Cell (2014), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013). A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track-record of publications in peer-reviewed journals; solid experience in the biochemistry of complex DNA-binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous _expression_ systems as well as their characterization using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.  Prior knowledge of crystallography is highly desirable. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. More information at http://www.deaconesculab.com

         Interested candidates should send a CV, one page research experience summary and contact information for three references to alexandra_deaconescu@brown.edu. Salary and starting date are negotiable.   Please write Postdoctoral Candidate in the e-mail subject header.   Brown University, an Ivy League school, is located less than one hour away by train from Boston.


At Brown University (Structural Biology)


The Deaconescu Lab at Brown University (Providence, RI) is seeking a highly motivated individual to work as a Research Assistant. The Deaconescu Laboratory focuses on structural studies by X-ray crystallography, small-angle X-ray scattering and electron microscopy of protein-protein and protein-nucleic acid complexes, particularly those involved in DNA repair and transcriptional regulation. The desired candidate will be responsible for performing routine lab work including media preparation, the preparation of solutions and stocks, cloning, large-scale protein _expression_, protein purification using an Akta chromatographic system, protein characterization using functional and biophysical methods (fluorescence, activity assays, circular dichroism, ITC), and protein crystallization. Additional responsibilities include performing general lab administration, which includes the organization and maintenance of lab databases and stocks, ordering, data entry and other duties as assigned. Applicant should be highly motivated with thorough, methodological and accurate work habits. The ideal candidate has a strong ability to multi-task and good communication skills.  More information at http://www.deaconesculab.com


Qualifications: Bachelor's or Master’s degree in a biological science or chemistry is required. Biological laboratory experience is required. Previous experience with molecular biology techniques (PCR, vector construction, nucleic acid extraction), protein _expression_, biochemistry (protein purification, enzyme assays, immunoblotting), protein crystallization are highly desirable. To apply, please send a CV, undergraduate transcript and contact information for three references to alexandra_deaconescu@brown.edu. Write “technician candidate” in the subject line. Position is available immediately, but start date is flexible.

Alexandra Deaconescu, B.E., Ph.D.
Assistant Professor
Brown University

Office: (401) 863-3215
Wet Lab: (401) 863-6729
Computational Lab: (401) 863-7031

For Mail:
Laboratories of Molecular Medicine
70 Ship St. GE-4
Providence, RI 02903

For Courier:
Laboratories of Molecular Medicine
Brown University
70 Ship St., Chestnut St. Loading Dock      
Providence, RI 02903

Website: www.deaconesculab.com

Mr. Ray Windsor
Email: Raymond_Windsor[at]brown.edu
Mailing Address:    
Box G-E, Brown University,
Providence, RI 02912-G
Telephone:     (401) 863-7446