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[ccp4bb] Senior Principal Scientist, Protein Engineering, Biologics Research at Sanofi
Senior Principal Scientist, Protein Engineering, Biologics Research
Framingham, MA, US
Job description:Sanofi tirelessly continues on its path towards becoming a world-class biologics organization and it is expanding the capabilities in this area. Global Biologics Research platform is one of the key cornerstones of this ambition, through its mission and key objectives to discover, design and generate novel biologics for research portfolio, and to develop and implement innovative state-of-the-art technologies. In order to further strengthen our Biologics Research technology powerhouse, we are seeking exceptional talents with a strong background in biologics and highly innovative and creative mindset.A highly motivated candidate is sought to join the Protein Engineering team with the US Sanofi Biologics Research organization. The individual will join and lead our crystallography efforts for determining the structures of complex biologics formats, including multi-specific antibody-antigen complexes, and carrying out structure-based analysis and designs. The individual will oversee a small team of PhD scientists working on X-ray crystallography, determining, analyzing and interpreting the structures to assist protein engineering efforts. The individual will work with project teams to assess and address sequence and structure-functions issues, and apply structure-based analysis and designs to improve therapeutic index of our Biologics R&D pipeline. The individual will have strong communication skills to collaborate effectively with team members and collaborators in protein _expression_, modification, and characterization areas, and to represent structural biology and protein engineering teams in project meetings and collaborations. This position will report to Head of Protein Engineering in US Sanofi Biologics Research.QualificationsPh.D. in protein crystallography or equivalent with a minimum of 10 years of relevant work experience, in either academic or Biotech and Pharmaceutical companies. Proven in-depth knowledge and expertise in protein structural biology demonstrated preferably through principal authorship in peer-reviewed publications. Specifically, candidates must have extensive experience in protein complex _expression_, purification, crystallization, data collection and structure determination with strong protein chemistry skills. Prior experience on antibody structure determination and structure-based design is highly desired. The candidate also needs to have excellent communication and presentation skills and work well in a team and matrix environment. Prior management experience is preferred.Sanofi is a global healthcare leader focused on patients' needs, engaged in the research, development, manufacturing, and marketing of therapeutic solutions focused on patients’ needs. Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets and Sanofi Genzyme.At Sanofi, our ambition is to be an integrated global healthcare company, focused on patients’ needs. Much more than just a leading pharmaceutical company, Sanofi is committed to transforming scientific innovations into solutions and services that protect health, enhance life, and respond to the needs of the 7 billion people in the world. We trust our ambition to guide and inspire us as we work to create a future with optimal health and wellness for everyone.