We are seeking a highly motivated and skilled PhD student for a protein engineering / structural biology project at the Paul Scherrer Institute (PSI) in Villigen, Switzerland. The aim of the project will be to engineer membrane proteins and membrane protein complexes that are suited for analysis by cryo-electron microscopy (cryo-EM) from single particles. The project will involve molecular cloning, protein _expression_ in E. coli and mammalian cells, protein purification, biophysical characterization and analysis by electron microscopy. Ideally, the student should have a strong interest in molecular and structural biology and a strong interest in the newest structural biology methods. Experience in electron microscopy, protein _expression_ in E. coli and mammalian cells, molecular cloning and protein purification would be highly beneficial. The project will be supervised by Dr. Roger Benoit and co-supervised by ETH Prof. Dr. Gebhard Schertler.
Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL
Head of Biology and Chemistry
Paul Scherrer Institut
Laboratory of Biomolecular Research,
CH-5232 Villigen PSI
phone +41 56 310 4265