A postdoc position is available in the group of Dr. Helgo Schmidt at IGBMC, Strasbourg, France. The research focus of our group is the dynein motor protein, a complex and fascinating molecular machine involved in essential cellular processes like mitosis, organelle positioning and the beating of cilia. (https://www.ncbi.nlm.nih.gov/pubmed/ 24064538). Our group studies the function of dynein motor complexes through an integrated structural biology approach combining x-ray crystallography and high-resolution cryoEM.
Applicants should have experience in cryoEM, molecular biology as well as protein _expression_ and purification. Additional knowledge and first hands-on experience in cryo-electron tomography would be considered a strong advantage. The position is funded for initially 2 years with the possibility of extension.
The IGBMC (http://www.igbmc.fr/) is one of the leading biomedical research institutions in Europe and provides regular synchrotron access as well as cutting-edge cryo-EM facilities like a Titan Krios electron microscope equipped with a Cs corrector, a GIF energy filter, a phase plate and a Gatan summit K2 direct electron detector. An ion beam scanning electron microscope (cryo-FIB/SEM) and super-resolution fluorescence microscopy for cellular tomography studies are also available.
Applicants should send a CV, a one-page summary of their research experience and contact details for two referees till 15th of October to firstname.lastname@example.org. The starting date is flexible.
Schmidt H (2015) “Dynein motors: How AAA+ ring opening and closing coordinates microtubule binding and linker movement.” Bioessays: 37: 532-543.
Schmidt H, Zalyte R, Urnavicius L, Carter AP (2015) “Structure of human cytoplasmic dynein-2 primed for its power stroke.” Nature 518: 435-438.
Schmidt H, Gleave ES, Carter AP (2012) “Insights into dynein motor domain function from a 3.3-Å crystal structure” Nat Struct Mol Biol. 19:492-7.