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[ccp4bb] Postdoctoral Fellowships in Structural Biology and Drug Development at NCMM, University of Oslo



Postdoctoral Fellowships in Structural Biology and Drug Development

Two postdoctoral positions (three years) are available in the Group of Structural Biology and Drug Development (Luecke group, hudel@ncmm.uio.no) at the Nordic Centre for Molecular Medicine (NCMM), the Norwegian node in the Nordic EMBL Partnership for Molecular Medicine.

The Group for Structural Biology and Drug Development investigates medically relevant proteins and protein complexes using biophysical, biochemical and structural approaches.  The projects aim at understanding structure-function relationships with an emphasis on drug discovery.  We employ a variety of biochemical and biophysical techniques (x-ray crystallography, single particle cryo electron microscopy, SAXS, ITC, SPR, molecular dynamics simulations etc.).  Specific projects include the Helicobacter pylori pH acclimation system of a pH-gated urea channel and a cytoplasmic urease and discovery of compounds that reactivate p53 cancer mutants in vitro and in vivo.

Strugatsky, D., McNulty, R.M., Munson, K., Chen, C.-K., Soltis, S.M., Sachs, G., Luecke H. “Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori” (2013) Nature 493, 255–258.
Luecke, H. & Sachs, G. “Helicobacter pylori’s Achilles’ Heel” (2013) Immuno-Gastroenterology 2, 76.
McNulty, R., Ulmschneider, J.P., Luecke, H., Ulmschneider, M.B. ”Mechanisms of molecular transport through the urea channel of Helicobacter pylori” (2013) Nature Communications 4, article number 2900.

Postdoctoral fellow

The positions are available starting January 2018.  We seek highly motivated individuals with an excellent track record and experience in protein purification and biophysical and biochemical characterization of proteins and protein complexes, preferably including membrane proteins.  Knowledge of structural biology techniques (x-ray crystallography and/or cryo electron microscopy) is required.  Postdoctoral fellows are expected to develop their own research area on their path to independence.  We offer a stimulating environment with excellent working and social benefits in the happiest country on Earth.

The ideal candidate will have: 

  • A Ph.D. degree in biochemistry, chemistry, molecular biology or a related area
  • Hands-on experience with extraction and purification of proteins and assembly of protein complexes (membrane protein experience preferred)
  • Ability to independently perform experiments, analyze and interpret results
  • Documented ability to write scientific manuscripts (one or more first author papers from Ph.D. and postdoctoral studies will be highly valued)
  • Excellent interpersonal/communication skills
  • Excellent written and oral English
  • Ability to operate as a team player in a multi-disciplinary environment

The online application (see link below, deadline 15 September 2017) must include:

  • A cover letter stating motivation and research interests
  • A C.V.
  • A complete list of scientific publications
  • List of references (name, relation to candidate, e-mail and telephone number)

Salary:

The postdoctoral position will be placed as Postdoctoral Research Fellow (SKO 1352) with a salary level of NOK486,100–569,000 (app. €51,800-€60,900) per year, depending on qualifications.

Inquiries:

About the position: Prof. Hartmut “Hudel” Luecke (hudel@ncmm.uio.no).
About administrative aspects of the application: Nina Modahl (ninam@ncmm.uio.no).

https://www.jobbnorge.no/en/available-jobs/job/141110/postdoctoral-fellowships-in-structural-biology-and-drug-development




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