The Fitzpatrick lab,
a member of the Zuckerman Mind Brain Behaviour Institute at Columbia
Situated in the heart of Manhattan, the Zuckerman Institute houses sixty laboratories employing a broad range of interdisciplinary approaches to transform our understanding of the mind and brain. In this highly collaborative environment, labs work together to gain critical insights into human health by exploring how the brain develops, performs, endures and recovers from trauma or disease.
In our lab, we leverage the latest developments in cryo-electron microscopy with complementary biophysical techniques (proteomics, light-microscopy, microfluidics) to explore the molecular basis of neurodegeneration (e.g. PNAS 110, 5468-5473 and Nature 547, 185-190). To this end, we determine the structure and function of protein complexes, purified directly from postmortem brain tissue, that are implicated in a range of neurodegenerative diseases. Additionally, we will visualize the behavior of these complexes within the cellular context using light-microscopy and cryo-electron tomography.
Members of the lab will have access to a state-of-the-art suite of electron microscopes:
In addition, two FEI Talos Arctica 200 kV microscopes with Gatan BioQuantum energy filters and K3 Summit direct electron detectors (housed separately at the Zuckerman Institute and Columbia University Medical School) and another Titan Krios microscope with Gatan BioQuantum energy filter and K3 Summit direct electron detector will be installed in early 2018.
We are looking for outstanding scientists who have a strong background in biophysics, biochemistry or neuroscience, and are highly motivated to learn single-particle cryo-EM. Prior experience with single-particle cryo-EM or X-ray crystallography is considered an advantage, but is not essential.
If you’re interested in joining our lab, please send your CV with a brief description of your current research, as well as 2-3 contacts for references, to firstname.lastname@example.org before the 18th of September, 2017.
Columbia University is an Affirmative Action/Equal Opportunity employer. Columbia values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.
Very best wishes,