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[ccp4bb] opening for Postdoctoral fellow - Pfizer Structural and Molecular Sciences

·         The successful candidate will join the Groton Structural and Molecular Sciences group which has extensive expertise in the gene to structure pipeline, in addition to biophysics and chemical biology.  Our mission is to provide integrated molecular insights into drug targets and target-ligand interactions to impact drug discovery efforts across multiple therapeutic areas.


The selected candidate will, in collaboration with others, perform research to understand protein-protein and protein-ligand interactions and the impact of ligand binding on target ubiquitination and degradation.  Responsibilities will include design of appropriate experiments, collecting and analyzing data, working independently in a laboratory environment in addition to performing other related duties, tasks and responsibilities as required.  The applicant training may/will include mammalian cell culture, molecular biology, protein _expression_ and purification, protein-ligand binding studies, in vitro assay development, and x-ray crystallography.  These efforts will be part of a larger team working to advance treatments for multiple diseases, as such you will have the opportunity to learn techniques from experienced colleagues throughout the Groton Structural and Molecular Sciences group and gradually build a broad understanding of other biology and chemistry disciplines involved in drug discovery.  This position offers an opportunity to help contribute to the understanding of a serious disease and will place the successful candidate into an environment rich with training opportunities, access to high level scientific equipment and excellent support for research materials.  You will be expected to present your results at an external meeting and publish your findings in high impact journals.


Basic Qualifications

o    Recent PhD in Biochemistry or a related field, or within 6 months of completion, and a track record of quality first authored publications

o    The successful candidate should have the desire and experience to carry out independent experiments and the creativity and drive to tackle challenging problems.  Successful candidates will possess excellent communication and collaboration skills to succeed in a team environment.


Matthew Calabrese

Senior Principal Scientist – Structural Biology and Biophysics