[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]

[ccp4bb] Trainee/student, undergraduate or master student Student internship

Job ID 213766BR
Position Title Master Student
Division NIBR
Business Unit CBT - NIBR
Country Switzerland
Work Location Basel
Company/Legal Entity Novartis Pharma AG
Functional Area Interns/Students on Novartis Payroll
Job Type Full Time
Employment Type Internship
Job Description Trainee/student, undergraduate or master student Student internship in the pharmaceutical industry in Protein Science Methods development for G-protein coupled receptors (GPCRs) Start and end dates [to be discussed]: 1 August 2017 – (nine to twelve months) 

We are looking for a highly motivated student with a strong interest in doing research in a pharmaceutical laboratory. The practical training involves _expression_ and purification scouting of a novel GPCR target (in insect-baculovirus & HEK293 systems). Focus will be a protocol development for GPCR detergents, buffer and purification scouting for functional homogeneity using combination of CESTA and semi-automatic Phynexus robot systems in a high throughput manner (see Ashok et al. 2015; Rehan & Jaakola, 2015 as example). Optimized conditions will be up-scaled and purified protein will be used biophysical screening (such as nanoDSF, SPR and fluorescence based probe assays) and X-ray crystallography. Results obtained during this work will be regularly presented and discussed within a multi-national and interdisciplinary team of experienced scientists

Minimum requirements University or TH master student in biochemistry, molecular biology, chemistry or life sciences Good knowledge of spoken and written English is required Experience in biophysics and/or biochemistry wet bench work and preferably basic knowledge of protein purification. Further training will be provided in the job. Ability to work in a team and interact with colleagues in a multicultural and multidisciplinary environment. Ability to work on different projects in parallel. Strong desire to learn and apply new methods in order to answer scientific questions. Open communication and precise way of working are important


Veli-Pekka Jaakola
Investigator III,
Novartis Institutes for Biomedical Research (NIBR),
Chemical Biology and Therapeutics (CBT),
Lab Jaakola,
Virchov 16-2.249.22,
Phone: +41 79 609 0014