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[ccp4bb] Postdoc position in structural biology of TGF-beta superfamily coreceptors, Karolinska Institutet



Dear all,

The research group of Luca Jovine at Karolinska Institutet has an opening for a postdoctoral fellow to study protein complexes involving TGF-beta superfamily coreceptors, with a focus on endoglin/CD105 - a key human glycoprotein involved in hereditary hemorrhagic telangiectasia type 1 (HHT1), preeclampsia and tumor angiogenesis. Parallel studies are also ongoing on a number of structurally related biological systems mediating fertilization as well as protection from bacterial infection.

For further information about our laboratory and recent examples, please see http://jovinelab.org and:

    Saito et al. Cell Rep. 19(9):1917–28 (2017) [ http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30636-8 ]

    Raj et al. Cell 169(7):1315–26 (2017) [ http://www.cell.com/cell/fulltext/S0092-8674(17)30594-9 ]

    Bokhove et al. Proc. Natl. Acad. Sci. USA 113(6):1552-7 (2016) [ http://www.pnas.org/content/113/6/1552.long ]

The Department of Biosciences and Nutrition of Karolinska Institutet has state-of-the-art equipment for protein _expression_ and purification, sample characterization (microscale thermophoresis, SEC-MALS) and in house X-ray/EM data collection (Rigaku Compact HomeLab with PILATUS 200K detector; http://ki.se/en/bionut/center-for-high-resolution-electron-microscopy-em). Frequent access to various synchrotron sites, as well as access to the newly established Cryo-EM Swedish National Facility (https://www.scilifelab.se/facilities/cryo-em/), are also available. With their close integration of academic and clinical research, KI and the Center for Innovative Medicine (CIMED; http://cimed.ki.se ) - to which our group also belongs - offer a highly international and collaborative environment for biomedical studies.

Candidates should have (or will be soon awarded) a PhD degree and must have significant experience in studying protein-protein interactions, both biochemically and using either X-ray crystallography or single-particle cryo-EM. Proven experience with the latter and/or protein _expression_ in eukaryotic cells will be a significant advantage. At least one first author paper in a high quality international peer-reviewed journal, fluency in English (both written and oral), good team spirit and a very strong personal drive to excel in science are required.

For more information about this position and to submit an application through the KI MyNetwork recruitment system, please see:


With best wishes,

Luca

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Luca Jovine, Ph.D.
Professor of Structural Biology
Karolinska Institutet
Department of Biosciences and Nutrition & Center for Innovative Medicine
Halsovagen 7, SE-141 83 Huddinge, Sweden
Voice: +46.(0)8.524-81136  FAX: +46.(0)8.6081-501
E-mail: luca.jovine@ki.se
W3: http://jovinelab.org
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