Schrödinger, a computational chemistry company funded in part by BIll Gates, has over 300 engineers, computational chemists, medicinal chemists, structural biologists, biochemists, biologists and support staff, all dedicated to revolutionizing drug discovery through the development and use of breakthrough computational methods. Through significant long-term investments in basic research, we have made scientific advancements across many areas of drug discovery and have contributed hundreds of peer-reviewed scientific publications, which are frequently among the most heavily cited in their fields. These advancements have been instrumental in the success of our structure-based drug discovery efforts, with three of our programs already in clinical trials and a fourth expected later this year. (https://www.schrodinger.com/publications, https://www.schrodinger.com/news)
We are now seeking a cryo-electron microscopy refinement specialist to join this interdisciplinary team in New York. This specialist will help us to combine our expertise in structure-based drug discovery with current breakthroughs in structural biology to further accelerate the drug discovery process.
-Refine and evaluate high resolution single particle cryo-EM data sets
-Actively participate in internal and collaborative structure-based drug discovery projects
-Work with the internal software development team to improve Schrödinger’s structure-based drug discovery technologies
-Ph.D. in structural biology, chemistry, biophysics, or a related field
-Hands-on experience working with single particle cryo-EM data collection for biological specimens
-Experience working with single particle cryo-EM refinement packages (EMAN, FreeAign, Relion, CryoSPARC, etc.), to refine high resolution data sets from biological specimens
-Strong communication skills
-Experience with methods to account for global and local structural heterogeneity in single particle cryo-EM data
-Knowledge of molecular modeling theory and applications
-Experience with pharmaceutical or biotechnology problems
-Python programming experience
Benefits include medical, dental, 401(k), flexible spending account, vacation, tuition reimbursement, and a flexible work schedule.
Schrödinger is an equal opportunity employer.
If interested, please apply through our website: https://www.schrodinger.com/careers/other-positions/cryo-em-refinement-specialist