POSTDOCTORAL POSITIONS AVAILABLE – CASE WESTERN RESERVE UNIVERSITY
STRUCTURAL BIOLOGY OF MEMBRANE REMODELING
Two NIH-funded postdoctoral positions are available immediately in the Ramachandran Lab at Case Western Reserve University (CWRU) to study the structural aspects of protein-mediated membrane remodeling during endocytic and mitochondrial membrane fission. These positions involve intensive collaboration with the labs of Jason Mears (cryo-EM, CWRU), Matthias Buck (NMR, CWRU), and Patrick van der Wel (ssNMR, University of Pittsburgh), and will also entail X-ray crystallography. The positions require a Ph.D. in biochemistry or biophysics with a focus on structural biology (X-ray crystallography, NMR, or cryo-EM). These positions will provide an excellent opportunity to learn and apply a wide array of structural and biophysical techniques to explore protein function on a model membrane surface. The Ramachandran laboratory also employs a host of cutting-edge spectroscopic approaches including FRET, fluorescence correlation spectroscopy (FCS) and fluorescence lifetime imaging (FLIM) to explore protein-protein and protein-membrane interactions in membrane remodeling and fission, both in vitro and in vivo. The Ramachandran lab and the facilities at CWRU are equipped with state-of-the-art instrumentation for both biophysical techniques and structural biology, as well as for protein purification, characterization and membrane reconstitution.
Requirements: Applicants must be highly motivated and must have demonstrated experience (i.e. relevant publications) in protein biochemistry and structural biology. The candidate should have a strong conceptual and experimental background in biochemistry and biophysics, as well as in the mechanistic dissection of structure-function relationships in proteins; he/she should be independent, proactive, hardworking and productive; only candidates that have first-author publications (or articles in press) will be considered. Candidates must have completed their PhD at the time of appointment. Salary will commensurate with experience and will adhere to current NIH guidelines. Interested candidates should submit their CV, reprints of selected publications, three reference letters (directly from referees), and a cover letter summarizing their experience, long-term goals, and estimated start date directly to Rajesh Ramachandran at email@example.com.
Relevant Publications. Please visit our webpage at https://physiology.case.edu/people/faculty/rajesh-ramachandran/