Details below of a position now open in my lab as part of a project to design and test inhibitors of protein-protein interactions.
Please Email me with any informal enquiries.
Research Fellow in Structural Molecular Biology
Are you looking to apply your skills in Structural Biology to the development of new approaches for discovery of protein-protein interaction inhibitors?
Protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Selective inhibition of individual PPIs would thus facilitate both a greater understanding of biological mechanisms and provide new opportunities for therapeutic intervention. Presently, PPI inhibitors represent a minute fraction of current small molecule drugs, this is largely because of specific challenges associated with development of inhibitors for these targets.
The Perturbation of Protein-Protein Interactions (PoPPI) project is a major £3.4 million five-year collaborative research programme led by Professor Andy Wilson, funded by the Engineering and Physical Sciences Research Council (EPSRC), and bringing together the University of Leeds, the University of Bristol, the Northern Institute of Cancer Research (Newcastle University) and drug discovery organisations, AstraZeneca and Domainex. This large and diverse programme focuses on developing, validating and exploiting new tools to discover inhibitors of PPI’s. This position will use structural biology and biophysics to assess the application of our methods for preparing inhibitors of multiple PPIs. The position will provide multiple opportunities for personal development, as well as the possibility of research secondments at Bristol and our drug discovery partners.
You should have, or be about to obtain, a PhD in Biochemistry or related biological science with expertise in Structural Chemistry. You will work closely, interactively and collaboratively with project team in an interdisciplinary setting, so you will need excellent communication skills, the ability to work under pressure and to meet deadlines.
To view the advert with details of how to apply use the link below:
Deputy Director Astbury Centre for Structural Molecular Biology
Ass. Professor, School of Molecular and Cellular Biology
University of Leeds, Leeds, LS2 9JT Telephone: 0113 343 3031
Invention, my dear friends, is 93% perspiration, 6% electricity, 4% evaporation, and 2% butterscotch ripple. ~Willy Wonka