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[ccp4bb] Higher Scientific Officer Position in Structural Biology and Biochemistry, ICR London, UK

Dear CCP4 Community,

I would like to draw your attention to a Higher Scientific Officer (HSO) position available in my team from 03 April 2017 on. For details, please see below. The application deadline is 01 March 2017.

Best wishes,

A Cancer Research UK-funded Higher Scientific Officer position is available from 03 April 2017 in the laboratory of Dr Sebastian Guettler in the Divisions of Structural Biology and Cancer Biology at The Institute of Cancer Research in London. We are looking for a highly motivated, organised and creative Higher Scientific Officer with a strong interest in the structural and functional characterisation of signalling proteins and multi-protein signalling complexes. Work in our laboratory centres on the elucidation of signal transduction mechanisms relevant to the maintenance and function of stem cells and cancer stem cells, in particular the Wnt/beta-catenin network and telomere homeostasis and their control by poly(ADP-ribosyl)ation. We take a multi-disciplinary approach that combines structural biology, both by X-ray crystallography and cryo-electron microscopy, biochemistry, biophysics and functional studies in mammalian cells. For a recent publication, please see Mariotti et al. (2016). Molecular Cell 63, 498–513. 

You will be responsible for general day-to-day lab management, provide high-level technical support for the production and biochemical characterisation of recombinant proteins and multi-protein complexes, and perform basic functional studies in mammalian cells. 

You should hold a BSc (or equivalent) in biochemistry or molecular biology. Extensive experience in recombinant DNA techniques and the _expression_ and purification of recombinant proteins is essential. Experience in protein production in insect cells (MultiBac), mammalian cell culture and a background in structural biology would be advantageous. 

Appointment will be on a Fixed Term Contract for 2 years and 3 months, with a starting salary in the range of £32,145 to £40,018 p.a. inclusive based upon relevance of skills and experience. 

Informal enquiries are welcome and can be made to Dr Sebastian Guettler (sebastian.guettler@icr.ac.uk). Please note, this address is for enquiries only, and you should not send your application to this email address. 

To apply please upload your CV and covering letter (addressing with specific examples how you meet the person specification and including the names and contact details of two referees) online.

Application deadline: 01 March 2017

Link to job description and application portal:

Sebastian Guettler, PhD | Team Leader

The Institute of Cancer Research | 237 Fulham Road | London | SW3 6JB | United Kingdom


W http://www.icr.ac.uk/our-research/research-divisions/division-of-structural-biology/structural-biology-of-cell-signalling | Twitter @ICRnews

Making the discoveries that defeat cancer

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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