I would really appreciate if you could share the info regarding this PhD available in my lab with any potential candidates. It's a 3.5 years studentship involving structural biology, protein biochemistry and biophysics and microbiology to study C. difficile surface layer proteins at the molecular level (more details below)
Attached is a flyer for circulating and the details on how to apply can be found here:
The student will be integrated in a Wellcome Trust Collaborative Award project, in collaboration with University of Glasgow and University of Sheffield. A second PhD is also available in Sheffield:
In this PhD, you will use a range of molecular biology, genetics, biochemistry and structural techniques to understand Clostridium difficile’s crystal shell. The PhD is part of a collaboration with the University of Sheffield and the University of Glasgow.
C. difficile is the most frequent cause of hospital acquired infections across Europe. This highly antibiotic resistant pathogen relies on antibiotics disrupting the gut microbiota to cause disease. We urgently need to develop species-specific antimicrobials that kill C. difficile without further disruption to the gut microbiota. The C. difficile cell is coated by a crystalline protein surface layer which is a promising but unexploited target for new therapeutics. Our work focusses on the structure, function and biogenesis of this crystal shell.
You will work alongside a postdoctoral scientist at the Newcastle University, with regular collaborative meetings with colleagues from Dr Rob Fagan’s (Sheffield) and Dr Gill Douce’s (Glasgow) groups. You will spend time in the other laboratories to offer a truly exceptional educational support experience, with maximal exposure to different expertise.
Dr Paula S. Salgado
Lecturer in Macromolecular Crystallography
Institute for Cell and Molecular Biosciences
Faculty of Medical Sciences
3rd Floor Cookson Building
Newcastle upon Tyne, NE2 4HH, UK
Tel: +44 (0)191 208 7432
Fax: +44 (0)191 208 7424