I’m looking for
an enthusiastic and highly motivated PhD student to join my newly established
group at IGBMC, Strasbourg, France. We are studying the structure and function
of the dynein motor protein through an integrated structural biology approach
combining x-ray crystallography and high-resolution cryoEM. The dynein motor is
a complex and fascinating molecular machine involved in essential cellular processes
like mitosis, organelle positioning and the beating of cilia (https://www.ncbi.nlm.nih.gov/pubmed/24064538).
should possess a Master’s or Bachelor’s degree in the life sciences, or a
related discipline. The applicant should have experience in molecular biology
as well as protein _expression_ and purification. Experience in protein
_expression_ in yeast and/or insect cells would be considered an advantage.
Training in x-ray crystallography and cryoEM will be provided. English language
skills, the ability to work in a team, initiative, flexibility as well as good
organizational and learning skills are required.
The IGBMC (http://www.igbmc.fr/) is one of the leading biomedical
research institutions in Europe and provides regular synchrotron access as well
as cutting-edge cryo-EM facilities like a Titan Krios electron microscope
equipped with a Cs corrector, a GIF energy filter, a phase plate and a Gatan
summit K2 direct electron detector. An ion beam scanning electron microscope
(cryo-FIB/SEM) and super-resolution fluorescence microscopy for cellular
tomography studies are also available.
should send a CV, a one-page summary of their research experience and contact
details for two referees till 31st of March to firstname.lastname@example.org.
The starting date is flexible.
(2015) “Dynein motors: How AAA+ ring opening and closing coordinates
microtubule binding and linker movement.” Bioessays:
Schmidt H, Zalyte R, Urnavicius L, Carter AP
(2015) “Structure of human cytoplasmic dynein-2 primed for its power stroke.” Nature 518: 435-438.
Gleave ES, Carter AP (2012) “Insights into dynein motor domain function from a
3.3-Å crystal structure” Nat Struct Mol