The Macias lab at IRB Barcelona has two open positions for highly motivated Structural Biologist PhD students to join our laboratory. Our research interest is focused on deciphering the mechanisms that correlate cell signaling with gene _expression_ using high resolution structural biology. We also aim at discovering how these mechanisms are regulated, and their consequent implications in human diseases from the structural point of view. Recently our work has been focused on the family of transcription factors Smads, where we have discovered a mechanism that labels these key components of the TGF-beta pathway first for activation and then for degradation.
Using NMR and X-ray crystallography we are currently characterizing the interactions of Smad proteins and cofactors with DNA promoters, to provide a first understanding of how these molecular machines work and to pave the basis for the design of small molecular inhibitors specifically targeted towards tumor-derived Smad forms.
Students should be ready to enter an official doctoral programme in September 2017.
Deadline is 15th of February of 2017.