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[ccp4bb] CryoEM position at Francis Crick Institute, London

Dear colleagues,


Applications are open for a cryo-electron microscopy scientist at the Francis Crick Institute in London to work in the Structural Biology Science Technology Platform. 

We are looking for a motivated, skilled electron microscopist who enjoys interacting with other scientists and will help with single-particle and tomography projects on our two recently acquired Titan Krios electron microscopes. 

Details pasted below and link found here:


For any questions, please contact Peter Rosenthal (Group Leader; peter.rosenthal@crick.ac.uk ), Alessandro Costa (Group Leader; alessandro.costa@crick.ac.uk ) or Phil Walker (Head, SB STP; philip.walker@crick.ac.uk)


Phil Walker

Peter Rosenthal

Alessandro Costa




Senior Laboratory Research Scientist – Cryo-electron Microscopy Scientist
Reports to Head, Structural Biology Science Technology Platform

Salary: Competitive with benefits, subject to skills and experience

This is a 5 year fixed term position on Crick Terms and Conditions of Employment. There are excellent opportunities for career advancement.


The Francis Crick Institute seeks to recruit a cryo-electron microscopy (cryo-EM) scientist to support single-particle and tomography projects.

The research scientist will be appointed to the Structural Biology Science Technology Platform (SB STP), which supports the Crick in the areas of protein science (_expression_ and purification), biophysics, X-ray crystallography, cryo-EM and related areas.

The post-holder will build on existing strengths at the Crick Institute in cryo-EM by interacting with members of the technology platform, research groups in cryo-EM, and other structural biology laboratories. There are excellent opportunities for career advancement.

The Francis Crick Institute is building a state-of-the-art facility for electron microscopy and computation and the post will consolidate excellence in these areas. Two FEI Titan Krios microscopes have recently been purchased and the installation and commissioning of the first of these should be completed in 2016.

There are excellent facilities for computing and expertise in experimental and computational aspects of cryoEM being developed through the structural biology platform.


These include but not limited to; 
• Support a range of cryo-EM research activities through interaction with Crick scientists including cryo-EM scientists and other structural biologists interested in cryo-EM.
• Contribute to management and maintenance of high-end cryo-electron microscopes
• Support experimental design including sample preparation and imaging of biological specimens. 
• Provide expertise and support in computational image analysis.

• Provide training in both experimental and computational aspects of cryo-EM.


The Francis Crick Institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The institute aspires to be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role — training scientists and developing ideas for public good.


The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:

• A higher degree in biological, physical, or engineering sciences. 
• Research experience and expertise in electron microscopy.
• Specialist knowledge of cryo-electron microscope operation and high-resolution data collection.
• Proven track record in three-dimensional electron microscopy.
• Excellent communication skills within a research environment, building highly effective working relationships with scientists and support staff.
• Plan time efficiently and be able to work both independently and in a team setting.

• PhD in Structural Biology or related areas.
• Experience in data analysis single particle images and/or tomography data.
• Experience with field emission gun microscopes and direct electron detectors.
• Postdoctoral experience in conducting cutting-edge research in cryo-EM.
• Authorship in peer-reviewed publications in internationally recognized scientific journals.
• Specialist knowledge of cryo-EM reconstruction software. 
• Knowledge of scientific computing including Unix shell scripting, Matlab, Python, programming languages.
• Flexible working practice.


For any questions, please contact us on jobs@crick.ac.uk, Peter Rosenthal (Group Leader; peter.rosenthal@crick.ac.uk ), Alessandro Costa (Group Leader; alessandro.costa@crick.ac.uk ) or Phil Walker (Head, SB STP; philip.walker@crick.ac.uk)

Please note: All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.