We are recruiting a postdoctoral scholar for a project that develops and experimentally tests new docking and drug discovery methods. We are looking for investigators trained in protein crystallography and biophysics.
The project develops experimental systems where new docking and simulation methods can be tested at atomic resolution, isolating individual terms. These include simple cavity sites, where each term can be isolated and evaluated in detail, -lactamase, which we have under full biophysical control, and ultimately GPCRs, where the new methods can have substantial biological impact. A longer description may be found at (http://www.bkslab.org/model_systems.php).
The project is a good introduction to current opportunities in structure-based drug discovery, and is stably funded by the NIH. Recent papers emerging from the project include:
• M Fischer et al. Incorporation of protein flexibility & conformational energy penalties in docking screens to improve ligand discovery. Nature Chemistry 6, 575-83 (2014). PMC4539595.
• N London, et al. Covalent Docking of Large Libraries for the Discovery of Chemical Probes. Nature Chem. Biol. 10, 1066-72 (2014). PMC4232467.
• M Merski et al., Homologous ligands accommodated by discrete conformations of a buried cavity. PNAS 112, 5039-44 (2015).PMC4413287.
• H Lee et al. Hydrogen Bonding of 1,2-Azaborines in the Binding Cavity of T4 Lysozyme Mutants: Structures and Thermodynamics. J Am Chem Soc. 138, 12021-4 (2016). PMC5087281.
The research environment at UCSF is outstanding, with active postdoctoral training programs, a weekly seminar series devoted to postdoctoral research, and three weekly seminars in chemical biology, drug discovery, and biophysics that draw scholars worldwide. The University is at the epicenter of biotechnology and is highly collaborative; it’s a great place to do research and build a career.