We have a PhD studentship available involving the innovative use of antibody-assisted structure-based drug discovery for cancer targets in the lab of Prof. Mark Carr, at the University of Leicester, and is in collaboration with the medical research charity LifeArc.
The PhD project will involve the generation of diverse panels of high affinity antibodies against several fully validated cancer drug targets to allow the identification, characterisation and exploitation of new opportunities for drug discovery. Structures obtained for a selected portfolio of antibodies bound to target proteins will provide an essential foundation for both structure-based design and fragment-based screening approaches to obtain small molecule modulators of activity that mimic the interactions seen with antibodies, providing a novel, potentially more effective route to new small molecule therapeutics.
The studentship is available for September 2018 and is fully funded for 3.5 years by the University of Leicester and LifeArc, and comes with an enhanced tax-free stipend of £17,500.
Attached is a flyer and further details can be found here:
Find A PhD:
The deadline for the application is 20th March 2018.
With kind regards,
Dr. Gareth Hall
Department of Molecular and Cell Biology, Henry Wellcome Building
University of Leicester, University Road, Leicester, LE1 7RH, UK
Description: MCB_LISCB_Carr 2018.pdf