We are seeking a highly motivated and determined membrane protein structural biologist for a UK research council funded position in Liz Carpenter’s group at the Structural Genomics Consortium in Oxford, to start asap.
Structural studies of human K2P potassium channels
- We will build on our successful program of solving K2P ion channel structures (Dong et al., Science, 2015)
- The K2P channels are responsible for excitability of nerve cells and are potential targets for migraine, pain and depression.
- We aim to understand regulation of these channels by physiological and pharmacological stimuli
- You will be using synchrotron and xFEL crystallography techniques to study the structures of a range of K2P channels
- You will use biophysical methods to understand function and identify novel binders
- You would also have the opportunity to be involved in structural studies of other potassium channels, using crystallography and electron microscopy
- This work is a collaboration with Stephen Tucker (Physics, Oxford) and Mark Sansom (Biochemistry, Oxford), for electrophysiology and MD simulations studies.
- Informal enquires to
- Closing date for applications:
Monday, 7th of November, 2016
- Please follow this link to apply for this post:
With best wishes,
Professor of Membrane Protein Structural Biology,
Structural Genomics Consortium,
Nuffield Department of Medicine,
University of Oxford.