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[ccp4bb] Post-doc opportunity in structural biology of ion channels

Dear all,

We are seeking a highly motivated and determined membrane protein structural biologist for a UK research council funded position in Liz Carpenter’s group at the Structural Genomics Consortium in Oxford, to start asap.


1.      Structural studies of human K2P potassium channels

  • We will build on our successful program of solving K2P ion channel structures (Dong et al., Science, 2015)
  • The K2P channels are responsible for excitability of nerve cells and are potential targets for migraine, pain and depression.
  • We aim to understand regulation of these channels by physiological and pharmacological stimuli
  • You will be using synchrotron and xFEL crystallography techniques to study the structures of a range of K2P channels
  • You will use biophysical methods to understand function and identify novel binders
  • You would also have the opportunity to be involved in structural studies of other potassium channels, using crystallography and electron microscopy
  • This work is a collaboration with Stephen Tucker (Physics, Oxford) and Mark Sansom (Biochemistry, Oxford), for electrophysiology and MD simulations studies.
  • Informal enquires to liz.carpenter@sgc.ox.ac.uk
  • Closing date for applications: Monday, 7th of November, 2016
  • Please follow this link to apply for this post: http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/125728-Postdoctoral-Research-Scientist---Integral-Membrane-Protein-Group


With best wishes,

Liz Carpenter


Professor of Membrane Protein Structural Biology,

Structural Genomics Consortium,

Nuffield Department of Medicine,

University of Oxford.