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[ccp4bb] PDRA position University of Manchester

Please see below for details of a current vacancy here at the University of Manchester. Informal enquiries should be made to Prof. Lydia Tabernero (Lydia.Tabernero@manchester.ac.uk).

The closing date for applications is the 22/11/18

Many thanks,


The University of Manchester


Faculty of Biology, Medicine and Health (FBMH)


Research Associate – Protein Crystallography

(Ref: BMH-12935)


  £32,236 - £35,211 p.a.  


Project Title

Inhibiting Dual-Specificity Tyrosine Phosphatases (DUSPs) as a Method for Preventing Resistance to Herceptin in Her2-Positive Breast Cancer


Project Description

You will work on an ambitious programme of structure-based drug discovery to produce novel drugs to overcome resistance to Herceptin in HER2-positive breast cancer.

Molecular and systems-level research during the past two decades have led to development of anti-cancer drugs that act by inhibiting specific molecules that play key roles in tumorigenesis process or in tumour survival. A prime example of this is Herceptin (trastuzumab), an antibody that inhibits HER2 and is used to treat HER2-positive breast cancer. Despite its effectiveness, two thirds of patients who respond to Herceptin develop resistance and relapse within one year. Understanding the molecular basis for such resistance and devising methods to prevent or reverse it are therefore of critical importance. Our aim is to design new inhibitors of protein phosphatases, which function downstream of HER2 and are key regulators of signaling and survival in breast cancer.

We are looking for an enthusiastic individual, highly motivated with efficient skills in time managing and project leading. This post offers an excellent opportunity to join a dynamic research team focused on drug development in the School of Biological Sciences (Faculty of Biology, Medicine and Health) with superb multidisciplinary facilities and stimulating working environment.

You must hold a PhD in Structural Biology/ Protein Crystallography/ Biochemistry and have a strong background in protein biochemistry and crystallisation.


Informal enquiries can be made to Prof. Lydia Tabernero.

Tel: 0161 2757794

Email Lydia.Tabernero@manchester.ac.uk

Application forms and further particulars can be obtained at http://www.manchester.ac.uk/aboutus/jobs/

Closing date: 22/11/2018

Please quote reference BMH-12935

Dr. Colin W. Levy
MIB G016
Tel.  0161 275 5090
Mob.07786 197 554

 Manchester Institute of Biotechnology | University of Manchester | 3.020 Garside Building | 131 Princess Street | Manchester | M1 7DN

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