Scientist
Protein Production and _expression_ within our Structural Biology Department
Salary: £19,825 – £33,500 + benefits
Location: Oxfordshire, UK
Must be eligible to work in UK
Full time; Permanent
Closing date for applications: 21 March 2011
Evotec (UK) Ltd is currently seeking to add to the Protein Production group within our Structural Biology Department based in Oxfordshire. The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs. The group is at the forefront of new science and technology, and is seeking to expand as business need grows.
Overview
The successful candidate will:
• Participate as part of a project team by designing, executing and interpreting high quality laboratory research to meet agreed objectives
• Apply scientific knowledge to resolve research problems encountered in achieving defined goals with some assistance from their line manager or other team members to meet internal and project deadlines.
• Prepare reports of findings, present data, and collaborate with other scientists at Evotec
Desirable Knowledge, Skills and Abilities:
• Protein _expression_ in E. coli
• Protein purification using affinity tags e.g. 6his tags
• Understanding of GE Healthcare Akta systems (e.g. Xpress, Purifier, Basic models) and Unicorn software.
• Purification of membrane proteins
• Protein production for crystallographic studies
• Cloning and design of synthetic gene constructs
• Crystallization of macromolecules
You will have excellent written and verbal communication skills and will be a strong team player. Dynamic, accurate and innovative, you will be a self-starter with a flexible approach who enjoys a challenge.
Education and Experience:
Educated to degree level or higher in a scientific discipline, or equivalent.
We offer extensive benefits including annual bonus, pension plan, private medical and dental cover.
If you feel that your skills and experience match what we are looking for, please apply by emailing your CV, a brief statement of research accomplishments and interests to humanresources-abingdon@evotec.com or to post it to:
Evotec (UK) Ltd
Human Resources
114 Milton Park
Abingdon
Oxfordshire
OX14 4SA
United Kingdom
About Evotec
Evotec is a leader in the discovery and development of novel small molecule drugs with operational sites in Europe and Asia. The Company has built substantial drug discovery expertise and an industrialised platform that can drive new innovative small molecule compounds into the clinic. In addition, Evotec has built a deep internal knowledge base in the treatment of diseases related to neuroscience, pain, and inflammation. Leveraging these skills and expertise the Company intends to develop best-in-class differentiated therapeutics and deliver superior science-driven discovery alliances with pharmaceutical and biotechnology companies.
Evotec has long-term discovery alliances with partners including Boehringer Ingelheim, CHDI, Novartis, Ono Pharmaceutical and Roche. Evotec has product candidates in clinical development and a series of preclinical compounds and development partnerships, including for example a strategic alliance with Roche for the EVT 100 compound family, subtype selective NMDA receptor antagonists for use in treatment-resistant depression.
Evotec (UK) Ltd is a limited company registered in England and Wales. Registration number:2674265. Registered Office: 114 Milton Park, Abingdon, Oxfordshire, OX14 4SA, United Kingdom