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[ccp4bb] Postdoc + technician positions - Structural Biology & Biophysics of E3 Ubiquitin Ligases

Ciulli Laboratory, School of Life Sciences, University of Dundee, UK

SLSC0161: Postdoctoral Research Scientist (Structural Cell Biology / Biophysics)

SLSC0162: Research Technician

We are seeking a highly motivated structural cell biologist / biophysicist (SLSC0161) and a research technician (SLSC0162) to join the laboratory of Dr Alessio Ciulli at the University of Dundee to work on an exciting drug discovery project funded by an industrial partner. The Ciulli lab is broadly interested in elucidating and characterising Protein-Protein Interactions (PPIs) important to human biology and relevant to human diseases, and targeting them using drug-like small molecules.

The project aims to develop novel small-molecule ligands and chemical probes targeting Cullin RING E3 Ubiquitin Ligases (CRLs) - the largest family of multisubunit ubiquitylating enzymes – using structure-based drug design. CRL-targeting probes can be used in their own right as E3 ligase modulators of the biological pathway in which the specific CRL is involved. In addition, CRL-targeting ligands can be suitably tethered with another ligand for a target protein of interest, yielding bifunctional compounds that hijack CRL activity and the ubiquitin proteasome system to induce targeted protein degradation. 

These are unique opportunities to gain experience in industry-style early-stage drug discovery within an academic setting.

For further information on the positions and to apply on-line, please visit

The following vacancy is also available on this project:
SLSC0160: Postdoctoral Research Scientist (Medicinal Chemistry / Chemical Biology / Organic Chemistry)

Closing Date: 31 October 2016

For informal enquiries please contact me directly by E-mail: a.ciulli@dundee.ac.uk

Best wishes,

 Alessio Ciulli PhD, FRSC
 Associate Professor in Chemical & Structural Biology
 Principal Investigator
 School of Life Sciences, University of Dundee
 Division of Biological Chemistry and Drug Discovery
 James Black Centre, Dow Street, Dundee DD1 5EH
 United Kingdom

 Phone: +44 (0)1382 386230    Fax: +44 (0)1382 386373