Two postdoctoral positions are available in Po-Lin Chiu's group at the School of Molecular Sciences at Arizona State University (ASU). The lab will physically locate in the Biodesign Building in Tempe campus. Our research focuses on the structural studies of membrane proteins, especially those of the receptor complexes in neuron axonal regeneration, and the main structural approach will be utilizing both single-particle cryo-EM and electron crystallography. In parallel, we are also interested in the technical development of cryo-EM method.
The ASU has its well-known name in the long history as an international leader in electron microscopy. The facility of the John M. Cowley Center for High-Resolution Electron Microscopy will install a new Titan-Krios equipped with a Volta phase plate and a Gatan K2 direct electron detector this October (see list: https://le-csss.asu.edu/equipment
). The FEI F20 electron microscope in the center will also be ready for biological cryo-EM use with modification. For EM sample screening, the CLAS Bioimaging Facility has a Philips CM12 and a JEOL 1200EX electron microscope (http://rts.clas.asu.edu/em
). The CLAS facility also has the high-pressure freezing equipment for sample preparation for electron tomography as well. In addition, the ASU also has a pioneer group leading the studies on femtosecond nanocrystallography using X-ray free-electron laser (XFEL), and we will have an excellent collaborative environment between structural biophysicists with different backgrounds.
Candidates should have a Ph.D. degree in the biology-related field or physical sciences. Preferred successful candidates will have the experiences in:
1. overexpression and purification of mammalian membrane proteins;
2. (optional) cryo-EM or X-ray crystallography experience;
2. signal processing (especially in pattern recognition);
3. (optional) programming skill in HPC demand.
The applicants must be self-motivated and team-oriented working with other lab members.
Applicants are invited to send their curriculum vitae and a list of contact information for two references to Po-Lin Chiu, Ph.D. (email@example.com
Po-Lin Chiu, Ph.D.
School of Molecular Sciences | Biodesign Institute
Arizona State University
1001 South McAllister Avenue
Tempe, Arizona 85287