CCP4 and Structural Genomics
Structural Genomics is a new interdisciplinary research area. The
current mass production of sequence data requires a comparable
systematic effort in protein structure determination. X-ray
Crystallography provides very accurate high resolution structures, and
large macromolecules and complex molecular assemblies are now
routinely tackled. These structures reveal the workings of biological
molecules which are crucial for rational drug design and the diagnosis
and treatment of disease, as well as in the advancement of the basic
principles of biology.
CCP4, as the providers of one of the largest and most comprehensive
software suites in protein crystallography, have a crucial role to
play in the structural genomics effort. The CCP4 interface "ccp4i" already
provides a means to automate the use of CCP4 programs, and we will
continue to develop these facilities so that the suite can be used
in routine high throughput structure determination.
Structural Genomics Initiatives
There are now many initiatives, and we cannot provide a comprehensive
list. Here is a short list of initiatives we have had some contact with.
CCP4 welcomes further contacts.